Me Mamu & 7 is about Mamu who is a gangster and believes 7 is his lucky number while his nephew Raj stays away from him due to illegal activities. Raj has a job but gets fired when the boss gets to know he is the nephew for a gangster, the gangster threatens the boss and Raj gets his job back and some paid holiday. On this holiday, he meets Prachi and falls in love with her.
On the other hand, Mamu makes a list of seven girls and when Raj marries one of them he will get 10 crore but Mamu dies in an accident. When Mamu is cremated his ghost appears and Mamu’s henchman also tells Mamu about the seven girls and not Raj has to deal with the ghost and somehow get also get married to Prachi.