Phamous revolves around Radhe (Jimmy Sheirgill), a student who is in love with his teacher and also in awe of guns. He once saves Kadak Singh (Kay Kay Menon), a local political gunda, from the police when he was summoned as a witness to identify Kadak as the killer. Kadak Singh is indebted to Radhe but is also highly dependent on Ram Vijay Tripathi (Pankaj Tripathi), who is always high on his libido, for political favors.
Radhe has a grudge against Tripathi as he raped and killed his teacher years ago. Kadak still managed to work with both until Tripathi started to eye Radhe’s wife (Shriya Sharan). In the meanwhile, Sambhu Singh (Jackie Shroff), the dhaakad in power before Kadak, is back to take the revenge of his daughter’s death.